Most people know hyaluronic acid from serums and creams. Increasingly, however, it is also being offered as drinkable ampoules or capsules. A study from the Czech Republic published in Scientific Reports in December 2025 has now investigated whether taking it has measurable effects on the skin.
How it was studied
150 healthy adults aged between 18 and 60 took part in the randomised, double-blind, placebo-controlled trial (Fitzpatrick skin types I–III, average age around 43). For twelve weeks, they drank 15 ml a day of a solution containing
- 60 mg sodium hyaluronate,
- 120 mg sodium hyaluronate or
- a placebo (xanthan).
High-molecular-weight hyaluronic acid (1.8 megadaltons) produced by microbial fermentation was used. Measurements included skin hydration, transepidermal water loss (a measure of the skin barrier), fine lines around the eyes, elasticity and skin density.
The results
- Cheek skin hydration (primary endpoint): +9.1 % (60 mg) and +11.5 % (120 mg) compared with placebo.
- Forehead: +8.7 % and +7.2 % compared with placebo.
- Forearm: no clear change.
- Skin barrier: transepidermal water loss on the cheek and forehead decreased in both hyaluronic acid groups.
- Fine lines around the eyes: significantly reduced, from the first month onwards.
- Elasticity and skin density: the usual decline was smaller in the 120 mg group.
- No differences in redness, pore size or shine. Side effects were rare, mild and similarly frequent in all groups.
How should this be interpreted?
The study is methodologically sound – randomised, blinded, with a placebo group and pre-registered. However, there are important limitations:
- Funding: the study was funded by the manufacturer Contipro and carried out at its site; six of the seven authors are employed there.
- Short duration of twelve weeks; the study ran from September to December, so seasonal influences on the skin are possible.
- No correction was made for the many outcome measures tested.
- Only lighter skin types were studied.
- How hyaluronic acid from the gut acts on the skin has not yet been clarified in humans; the explanatory models come mainly from animal experiments.
Notably, in their subjective self-assessment, all groups – including the placebo group – felt better hydrated.
Conclusion
The study provides evidence that oral hyaluronic acid can moderately improve facial skin hydration. The effects are measurable but limited and should be confirmed by independent, longer studies. Sun protection, not smoking and good basic skincare remain the most effective measures for healthy skin.
Note: This article is for general information only and does not replace advice from a doctor or dermatologist. Dietary supplements are not a substitute for a balanced diet.
